Acute Confusional Migraine in an Adolescent: Response to Intravenous Valproate abstract

Acute confusional migraine (ACM) is a dramatic, rare manifestation of migraine describedmostly for children and adolescents. There are few data on the treatment of an ACM attack. Prochlorperazine has been suggested as an effective drug. The authors of some reports have suggested that valproic acid may play a role in the prevention of ACM and as treatment for acute migraine headache in the adult population. However, this medication has not been reported as first-line, acute therapy for ACM. We report here the case of a 12-year-old girl who presented with an ACM attack that resolved rapidly after intravenous administration of valproic acid. Pediatrics 2010;125:e956–e959 AUTHORS: Shelly Ben Avraham, MD,a Miki Har-Gil, MD,b and Nathan Watemberg, MDb aDepartment of Pediatrics and bChild Neurology Unit, Meir Medical Center, Tel Aviv University, Kfar Saba, Israel